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Palmoplantaire hyperkeratose

Autosomal recessive palmoplantar keratoderma and

Hyperkeratotic palmar dermatitis DermNet N

  1. Acquired palmoplantar keratoderma is more likely to present in adulthood (compared with inherited keratodermas which usually present in childhood). It presents with thickening of the skin of the palms and/or soles which may be diffuse (involving most of the palms and soles) or focal (localised mainly to pressure areas)
  2. Palmoplantar pustulosis is an uncommon chronic pustular condition affecting the palms and soles. It is also called pustulosis palmaris et plantaris. It is related to a common skin condition, psoriasis. A variant of palmoplantar pustulosis affecting the tips of the digits is called acrodermatitis continua of Hallopeau or acropustulosis
  3. Diffuse palmoplantar keratoderma is a type of palmoplantar keratoderma that is characterized by an even, thick, symmetric hyperkeratosis over the whole of the palm and sole, usually evident at birth or in the first few months of life

C Clinical test, R Research test, O OMIM, G GeneReviews. C R O G Palmoplantar hyperkeratosis. IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a. A form of epidermolytic hyperkeratosis that is limited to the palms and soles, designated palmoplantar keratoderma (EPPK; 144200), is caused by mutation in the keratin gene KRT9 (607606), and a mild form of EPPK can also be caused by mutation in KRT1 Diffuse palmoplantar hyperkeratosis is a characteristic sign which may extend to the dorsum of the hands and feet (4). However, our case had no transgradient component. There are other less common abnormalities reported in Clouston syndrome, which include conjunctivitis, strabismus, congenital cataract, oral leucoplakia, diffuse eccrine. Use of arsenic-induced palmoplantar hyperkeratosis and skin cancers to predict risk of subsequent internal malignancy Am J Epidemiol. 2013 Feb 1;177(3):202-12. doi: 10.1093/aje/kws369. Epub 2013 Jan 7. Authors Ling-I Hsu 1. People with PS-type epidermolytic hyperkeratosis have thick skin on the palms of their hands and soles of their feet (palmoplantar or palm/sole hyperkeratosis) in addition to other areas of the body. People with the other type, NPS-type, do not have extensive palmoplantar hyperkeratosis but do have hyperkeratosis on other areas of the body

Palmoplantar keratoderma Genetic and Rare Diseases

Keratoderma climactericum - characterised by hyperkeratosis of the palms and soles in women of menopausal age, and associated with obesity and hypertension. It usually affects the sole of the feet around the margins of the heel and under the metatarsal heads. The palms of the hands may be affected with discrete, centrally placed lesions Palmoplantar pustulosis is usually initially managed with intermittent ultrapotent topical steroids (continuous treatment aggravates the condition), crude coal tar ointment, and/or emollients. If palmoplantar psoriasis is severe and interferes with function (painful to walk or work), refer to a dermatologist Palmoplantar keratoderma (PPK) is a dermatosis that presents as hyperkeratosis of the palms and soles. It may be acquired or heritable. Acquired PPK often occurs as a paraneoplastic response as well as a stigma of other dermatoses. We report a rare case of a 72-year-old woman with acquired PPK secondary to metastatic uterine adenocarcinoma

Chronic arsenic arsenicosis causes palmoplantar hyperkeratosis which is also seen in Papillon-Lefevre syndrome. Papillon-Lefevre syndrome is a rare disease characterised by skin lesions caused by palmar-plantar hyperkeratosis and severe periodontal destruction involving both primary and permanent dentitions.. A 20-year-old unmarried, young girl of South Bengal diagnosed with symmetrical. Nagashima-type palmoplantar keratoderma is an autosomal recessive nonsyndromic diffuse palmoplantar keratosis, first described by Nagashima (1977) in the Japanese literature. It is characterized by well-demarcated diffuse erythematous hyperkeratosis that extends onto the dorsal surfaces of the palms and feet and the Achilles tendon area

A patient with alopecia, nail dystrophy, palmoplantar hyperkeratosis, keratitis, hearing difficulty and micrognathia without GJB2 or GJB6 mutations: a new type of hidrotic ectodermal dysplasia? Br J Dermatol. 2007 Apr;156(4):777-9. doi: 10.1111/j.1365-2133.2007.07752.x.. Palmoplantar hyperkeratosis (PPK) and predisposition to squamous cell carcinoma of the skin (SCC) segregated as recessive traits. All members of the family with PPK were phenotypic males (46,XY or 46,XX), whereas 7 XX sibs were healthy phenotypic females with no signs of PPK A rare, isolated, diffuse palmoplantar keratoderma disorder characterized by red-yellow, moderate to severe hyperkeratosis of the palms and soles, extending to the dorsal aspects of the hands, feet and/or wrists and involving the skin over the Achilles' tendon (transgrediens), gradually worsening with age (progrediens) to include patchy hyperkeratosis over the shins, knees, elbows and. Palmoplantar keratoderma (PPK) is an inherited or acquired condition characterized by diffuse or localized hyperkeratosis of the palms and soles. The acquired form has been described as a paraneoplastic finding in a variety of malignancies or can develop, as well as a result of direct involvement of the skin by cutaneous T-cell lymphoma (CTCL) Palmoplantar papules - a chronic skin condition. This article describes the case of a 68-year-old female patient who presented to the dermatology clinic with slowly progressing, yellowish, hyperkeratotic papules and plaques on the hands and feet. However, the patient did not complain of any pain, itching, nail changes or skin fragility

Palmoplantar keratoderma DermNet N

Footnote: (A) Generalized hyperkeratosis with background erythema of the lower limbs; (B) palmoplantar hyperkeratosis extending proximally, typical of epidermolytic hyperkeratosis. Epidermolytic hyperkeratosis causes. Mutations in the keratin 1 (KRT1) or keratin 10 (KRT10) genes are responsible for epidermolytic hyperkeratosis Punctate palmoplantar keratoderma is a feature of Buschke-Fischer-Brauer disease, focal acral hyperkeratosis, acrokeratoelastoidosis and punctate porokeratosis, which, however, manifest later in life (5). The last two are distinguishable by characteristic histological features, i.e. cornoid lamellae and parakeratosis or disorganized elastic fibres Affected individuals have palmoplantar hyperkeratosis, with thickening and dyskeratosis of the entire soles and parts of the palms There can Darier disease View in Chinese punctate keratoses, pits, and, less frequently, hemorrhagic macules Hereditary palmoplantar keratoderma (PPK) is a heterogeneous group of disorders characterized by hyperkeratosis of the palm and the sole skin. Hereditary PPK are divided into four groups - diffuse, focal, striate and punctate PPK - according to the clinical patterns of the hyperkeratotic lesions

Paraneoplastic palmoplantar keratoderma (PPK) is an acquired dermatosis that presents with hyperkeratosis of the palms and soles in association with visceral malignancies (eg, esophageal, gastric, pulmonary, and urinary/bladder carcinomas). Palmoplantar keratoderma secondary to uterine cancer is rare Palmoplantar keratoderma is a heterogeneous group of hereditary and acquired disorders characterized by abnormal thickening of palms and soles. Hypothyroidism is an unusual cause of palmoplantar keratoderma, rarely reported in the literature. We report a case of a 43-year-old woman presented with a 3-month history of a diffuse palmoplantar hyperkeratosis unresponsive to topical keratolytics. Fig. 24.1 Upper panel demonstrates a young African-American woman with palmoplantar discoid lupus erythematosus. Note the loss of pigmentation, erythema, and hyperkeratosis at the center and hyperpigmentation at the periphery. Lower panel demonstrates discrete reddish hyperkeratotic plaques limited to the palms in a patient with chronic hyperkeratotic eczema Case A patient presents with an. EHK is a rare autosomal dominant disorder of keratinization, caused by mutations in either the KRT1 or KRT10 genes. Although palmoplantar keratoderma is typically found in patients with KRT1 mutation, our patient presents EHK with palmoplantar involvement and KRT10 mutation. Moreover, a poor response to systemic retinoids was observed, contrary.

Alerts and Notices Synopsis Palmoplantar keratoderma (PPK) is thickening of the palms and/or soles that cannot be attributed to friction alone. Cases are either inherited or acquired. Heritable PPKs are identified by the presence of a family history and childhood onset; they may manifest in isolation, as the defining feature of a syndrome, or as a minor aspect of a syndrome (eg, congenital. Histologically, the papules demonstrated hyperkeratosis, without columns of parakeratosis. A diagnosis of type I hereditary punctate keratoderma (Buschke-Fisher-Brauer disease) was made. This condition, which is classified as one of the three hereditary forms of punctate palmoplantar keratoderma, is an autosomal-dominant condition with variable.

Hereditary palmoplantar keratoderma: A practical approach to the diagnosis Tanvi Dev 1, Vikram K Mahajan 2, Gomathy Sethuraman 1 1 Department of Dermatology, All India Institute of Medical Sciences, New Delhi, India 2 Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra (Tanda), Himachal Pradesh, Indi The Papillon-Lefèvre and Haim Munk syndromes are characterized by the presence of both palmoplantar hyperkeratosis (PPK) and severe early onset periodontitis. It is the early onset periodontal disease component that distinguishes these from other more common forms of PPK. It has been proposed that t Palmoplantar hyperkeratosis or keratoderma with transgradiens iii. Hyperpigmentation of the skin over the joints, at the axillae, areolae, and pubic area iv. Thickened skin over the knees, elbows, and hand joints v. Normal sweating 42. NAIL FINDINGS i. Milky white nail plates in childhood ii. Nail plates become progressively short, dark and.

Original Article Mutations of Keratin 9 in Two Families with Palmoplantar Epidermolytic Hyperkeratosis Jeannette M Bonifas, 1 Kunie Matsumura, 1 Marisa A Chen, 1 John Berth-Jones, * Peter E Hutchinson, * Michael Zloczower, 3 Peter O Fritsch, 3 Ervin H Epstein, Jr. 1 1 Department of Dermatology, University of California School of Medicine, San Francisco, CA, U.S.A. Department of Dermatology. Punctate Palmoplantar Hyperkeratosis Symptom Checker: Possible causes include Ovarian Cyst. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search

302 Found

Punctate palmoplantar keratoderma type I Genetic and

Abstract We report the case of a 12‐year‐old girl with juvenile dermatomyositis (JDM). She had a 12‐month history of palmoplantar hyperkeratosis that was initially treated as eczema. We wish to ale.. The parakeratotic column in palmoplantar filiform hyperkeratosis originates from the granular layer and at first glance resembles the comoid lamellae of porokeratosis.2' 3, 5, 7, 9, is This resemblance was probably the reason that Zarour et al. coined the term palmoplantar porokeratotic fzliform hyperkeratosis for these lesions

Palmoplantar Keratodermas - Dermatology Adviso

  1. Acquired palmoplantar keratoderma. Am J Clin Dermatol. 2007;8:1-11. Deschamps P, Leroy D, Pedailles S, et al. Keratoderma climactericum (Haxthausen's disease): clinical signs, laboratory findings and etretinate treatment in 10 patients. Dermatologica. 1986;172:258-262. Wachtel TJ. Plantar and palmar hyperkeratosis in young castrated women. Int.
  2. histological feature of acquired palmoplantar keratosis is hyperkeratosis, which may occur with acanthosis and/or varying degrees of parakeratosis, hyperplasia of the stra-tum spinosum and granulosum, and perivascular infiltrati-on of inflammatory cells. The clinical appearance is usual-ly unspecific; hyperkeratosis of the stratum corneum is th
  3. Keratinization disorder which presents at birth with generalized erythema, widespread bullae and desquamation resulting in denuded skin Form of ichthyosis, an abnormality of epidermal maturation resulting in skin fragility Epidermolytic hyperkeratosis is a descriptive term which refers to specific microscopic features (i.e. vacuolar degeneration of the spinous layer, keratin filament.

Keratoderma palmoplantaris - Huidziekten

People with nonepidermolytic palmoplantar keratoderma have palmoplantar hyperkeratosis with no evidence of epidermolysis. In striate palmoplantar keratoderma type 3, the skin thickening on the palms and soles follows a specific pattern. KRT1 gene mutations are also responsible for a skin disorder called Curth-Macklin ichthyosis hystrix. This. Introduction. Pachyonychia congenita (PC) is a rare form of hereditary palmoplantar keratoderma (PPK) (Smith et al., 2001) and is a genetic disorder of keratinization that affects the nails, skin.

Acquired keratoderma DermNet N

It is characterized by photophobia due to keratitis, painful palmoplantar hyperkeratosis, variable mental retardation, and elevated serum tyrosine levels. Patients are often misdiagnosed with herpes simplex keratitis [Buist et al 1995, Macsai et al 2001, Krol and Siegel 2012]. A low-protein diet (<0.6 g/kg/day) was implemented The lesions of the hands consist of a streak of hyperkeratosis running the length of each finger and onto the palm. Bologna (1966) reported a 4-generation kindred in which involvement of males predominated in a striking manner. This disorder is also referred to as the Brunauer-Fohs-Siemens type of palmoplantar keratoderma Epidermolytic hyperkeratosis is an abnormality of epidermal maturation characterized by compact hyperkeratosis, accompanied by granular and vacuolar degeneration of the cells of the spinous and granular layers (Fig. 9.11).It may be a congenital or an acquired defect. This histological pattern may be seen in a number of different clinical settings, some of which will be considered in other. In the proband of one family affected with cyclic ichthyosis with epidermolytic hyperkeratosis, Sybert et al. (1999) found a 1436T-C transition mutation in the keratin 1 gene that predicted an amino acid change from isoleucine to threonine at codon 479 (I479T; 139350.0005).This alteration in the highly conserved portion of helix 2B, known as the helix termination motif, created a new BsmAI. No-palmoplantar-hyperkeratosis Symptom Checker: Possible causes include Pachyonychia Congenita. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search

Palmoplantar pustulosis DermNet N

Treatment. Although treatment of the condition is not satisfactory yet, various topical treatments (namely 6% and 12% salicylic acid in white soft paraffin, [19,20,21] 6% salicylic acid in 70%. Dermatopathic pigmentosa reticularis. Syndromic keratodermas. Vohwinkel syndrome. Palmoplantar keratoderma associated with esophageal cancer. Palmoplantar keratoderma and spastic paraplegia. Naxos disease. Striate palmoplantar keratoderma, woolly hair, and left ventricular dilated cardiomyopathy. Keratitis-ichthyosis-deafness syndrome Human Phenotype Ontology, a standardized vocabulary of phenotypic abnormalities encountered in human disease. With unmatched depth it enables clinicians to record and analyse data with extremely accurate computer interpretable ontology terms. Developed by The Monarch Initiative

Pityriasis rubra pilaris (PRP)

A single male Rottweiler dog with severe footpad hyperkeratosis starting at an age of eight weeks was investigated. The hyperkeratosis was initially restricted to the footpads. The footpad lesions caused severe discomfort to the dog and had to be trimmed under anesthesia every 8-10 weeks. Histologically, the epidermis showed papillated villous projections of dense keratin in the stratum corneum Meleda Disease is a skin condition which usually can be identified not long after birth. This is a genetic condition but it is very rare. The hands and feet usually are the first to show signs of the disease but the disease can advance to other parts of the body. Signs of the disease include thickening of the skin, on hands and soles of feet. Various sources of research on Corneal Intraepithelial Dyskeratosis-Palmoplantar Hyperkeratosis-Laryngeal Dyskeratosis Syndrome. Financial Resources. Information about disability benefits from the Social Security Administration Palmoplantar keratoderma is a generic term for diseases that hereditarily cause hyperkeratosis in the palms and soles. It is sub-classified by clinical features and patterns of inheritance (Figs. 15.15-1 and 15.15-2; Table 15.4). Genetic mutation is identified in some cases. Further clarification is necessary for exact classifi

Primary biliary cirrhosis (PBC) is an autoimmune disease of the liver characterized by the presence of highly specific antimitochondrial antibodies with resulting immune-mediated injury of small intrahepatic bile ducts.1 Palmoplantar keratodermas (PPKs) are characterized by hyperkeratosis of the skin on the palms and soles.2 Multiple cases have been reported associating PPK with autoimmune. Palmoplantar keratodermas are rare inherited disorders characterized by palmar and plantar hyperkeratosis. Palmoplantar keratodermas encompass a broad range of inherited disorders. They may be categorized based on degree of skin involvement (eg, localized to the palms and soles, expanding to involve other cutaneous sites and adnexal structures.

Palmoplantar keratoderma - Wikipedi

Palmoplantar hyperkeratosis in Irish terriers: evidence of autosomal recessive inheritance. H. Binder, Department of Reproduction, Faculty of Veterinary Medicine, University of Zürich, Winterthurerstrasse 260, 8057 Zürich, Switzerland. Search for more papers by this author In 1971, Schopf et al 1 described the syndrome of multiple eyelid apocrine hidrocystomas, palmoplantar hyperkeratosis, hypodontia, and hypotrichosis. Since then, 20 cases (13 reports) have been reported in the literature. 1-8 Multiple apocrine hidrocystomas of the eyelids have been described and can occur unrelated to this syndrome. Schopf-Schulz-Passarge syndrome, which is characterized as a. Bullous pemphigoid with hyperkeratosis and palmoplantar keratoderma: Three cases. Luca Fania. Corresponding Author Nili, Soheil Tavakolpour, Kamran Balighi, Maryam Daneshpazhooh, Hamidreza Mahmoudi, Concomitant bullous pemphigoid and palmoplantar keratoderma: A report of three cases and review of literature, Dermatologic Therapy, 10.1111.

Palmoplantar hyperkeratosis - Conditions - GTR - NCB

  1. The Ministry of Health of Viet Nam is actively providing intervention measures to treat people as well as prevent, investigate and monitor the development of new cases of inflammatory palmoplantar hyperkeratosis syndrome (IPPH) in Ba To district Quang Ngai province in Central Viet Nam. The Ministry of Health has been actively supported in it's response to the situation in the affected area.
  2. small intrahepatic bile ducts.1 Palmoplantar kerato-dermas (PPKs) are characterized by hyperkeratosis of the skin on the palms and soles.2 Multiple cases have been reported associating PPK with autoim-mune thyroiditis.3 Herein, we report a patient with acquired PPK who was diagnosed with PBC. Treatment of her PBC led to clearance of her PPK.
  3. A 62-year-old white man presented with multiple asymptomatic eyelid cysts that had gradually increased in number over the past 20 years. He also had palmoplantar hyperkeratosis, which had increased in severity after he underwent a cadaveric renal transplantation for end-stage renal disease due to focal glomerulosclerosis 3 years earlier
  4. A palmoplantar keratoderma (excessive callus formation on palms and soles) and/or hair abnormalities may be present in some forms of the disorder. Introduction The term epidermolytic ichthyosis was agreed upon by the International Ichthyosis Consensus Group in 2009 and replaces the older, confusing labels of bullous congenital ichthyosiform.
  5. ation revealed disfiguring palmoplantar keratoderma (Figure 1), coalescing hyperkeratotic papules on the upper trunk area (Figure 2), and similar..
  6. Coco Skin Plus: https://amzn.to/2Q5fPZyPopper Tool Kit: https://amzn.to/2XohQiNRESTMORE (30 Day): https://amzn.to/2Imw79uBlackhead Facia..

Mutations in connexin 26 ( GJB2 , Cx26 ) cause autosomal recessive and occasionally dominant non-syndromic sensorineural hearing loss (SNHL). Cx26 mutations have also been identified in SNHL with dermatological features of autosomal dominant diffuse palmoplantar hyperkeratosis (DPPK).1-3 We describe a girl with bilateral sloping sensorineural hearing loss, striate palmoplantar hyperkeratosis. Palmoplantar keratodermas 2.Focal type: localized areas of hyperkeratosis located mainly on pressure points and sites of recurrent friction 14. Palmoplantar keratodermas 3.Punctate type: multiple small, hyperkeratotic papules, spicules, or nodules on the palms and soles may involve the entire palmoplantar surface or may be restricted to certain. Palmoplantar hyperkeratosis with a linear disposition along dermatoglyphics: A clue for an early diagnosis of tyrosinemia type II. Giornale Italiano di Dermatologia e Venereologia , 152 (2), 182-183 Autosomal dominant palmoplantar hyperkeratosis and congenital alopecia; Palmoplantar keratoderma and congenital alopecia, Stevanovic type; Overview. No overview is available at this time. Please check back for future updates. For more information, visit GARD. Search Rare Diseases

Palmoplantar hyperkeratosis (Concept Id: C0022596

Fokales palmoplantares und orales Mukosa-Hyperkeratose-Syndrom. Focal palmoplantar and oral mucosa hyperkeratosis syndrome. Gudrun Bethke 1, Gerhard Kolde 2, Gösta Bethke 1 & Peter A. Reichart 1 Mund-, Kiefer- und Gesichtschirurgie volume 5, pages 202-205 (2001)Cite this articl Palmoplantar keratoderma (PPK) constitutes a heterogeneous group of disorders characterized by thickening of the palms and the soles of individuals who are affected. In recent years, speculation has arisen that a molecular genetic classification system will replace the traditional, clinically based, descriptive systems Ling-I Hsu, Gwo-Shing Chen, Chih-Hung Lee, Tse-Yen Yang, Yu-Hsin Chen, Yuan-Hung Wang, Yu-Mei Hsueh, Hung-Yi Chiou, Meei-Maan Wu, Chien-Jen Chen, Use of Arsenic-Induced Palmoplantar Hyperkeratosis and Skin Cancers to Predict Risk of Subsequent Internal Malignancy, American Journal of Epidemiology, Volume 177, Issue 3, 1 February 2013, Pages 202. Incidence of palmoplantar hyperkeratosis was similar in the vemurafenib and dabrafenib groups (6% vs 8%). 3,9 Development of keratoderma also has been associated with other multikinase inhibitors (eg, sorafenib, sunitinib). 10,11. In our case, the patient displayed multiple side effects while undergoing vemurafenib therapy The Invitae Epidermolysis Bullosa and Palmoplantar Keratoderma Panel analyzes genes that are associated with epidermolysis bullosa, palmoplantar keratoderma, and related conditions, which are characterized by skin fragility or thickening of the skin on the palms and soles. These genes were selected based on the available evidence to date to provide a broad analysis for inherited epidermolysis.

Diffuse Palmoplantar Keratoderma, Onychodystrophy

Palmoplantar keratodermas (PPKs) are a diverse entity of disorders that are characterized by abnormal thickening of the skin on the palms and soles. Traditionally they have been classified as either hereditary or acquired and are distinguished from each other on the basis of mode of inheritance, presence of transgrediens (defined as contiguous extension of hyperkeratosis beyond the palmar and. We present here the third published case of palmoplantar orthokeratotic filiform hyperkeratosis of particular clinical interest because of associated Darier's disease. We propose a classification of filiform hyperkeratosis in three groups on the basis of the topography (i.e. palmar and plantar. Palmoplantar hyperkeratosis in Irish terriers: evidence of autosomal recessive inheritance At the age of six months, the affected animals developed smooth parchment‐like footpads. The pad epidermis then hardened and grew lateral cone‐like protrusions of up to 5 mm in diameter Palmoplantar keratoderma of Sybert Aimee L Leonard MD, and Irwin M Freedberg MD Dermatology Online Journal 9(4): 30 From the Ronald O. Perelman Department of Dermatology, New York University Abstract. A 13-year-old boy and a 7-year-old boy, who are brothers, presented with a life-long history of erythema, hyperkeratosis, and desquamation of the hands and feet

Use of arsenic-induced palmoplantar hyperkeratosis and

  1. Cutaneous adverse effects of imatinib mesylate (Glivec) are common and various types of skin eruptions have been reported. We report here a 57-year-old man who presented with lichen planus-like lesions on his extremities and palmoplantar hyperkeratosis due to the use of imatinib mesylate for chronic.
  2. Woolly hair and palmoplantar hyperkeratosis is an infrequent autosomal recessive ectodermal disorder that may be associated with arrhythmogenic right ventricular dysplasia (Naxos disease) or dilated cardiomyopathy. We report the sporadic occurrence of the aforementioned skin-hair anomalies in a patient with physical findings compatible with Noonan's syndrome and hypertrophic cardiomyopathy.
  3. Orthokeratotic hyperkeratosis was strikingly exquisite. Nonetheless, a variable degree of hypergranulosis and acanthosis was noticeable (Figure 4). Soles affected by palmoplantar keratoderma.
  4. ation of a biopsy showed the typical features of lichen nitidus
Differentiele diagnose van reticulaire hyperpigmentatie

Main features: Nail changes, palmoplantar hyperkeratosis, follicular hyperkeratosis (thickened horny plugs) on the face and extensor surfaces of the limbs, oral leukokeratosis (whitish areas. Plantar hyperkeratosis Neoplasm Failure to thrive Scoliosis Global developmental delay Diffuse palmoplantar hyperkeratosis Patchy palmoplantar keratoderma Abnormality of [mendelian.co] [] the soles, high-arched palate , and left-handedness are other clinical features